Pharmacokinetics, safety, and tolerability of gepotidacin administered as single or repeat ascending doses, in healthy adults and elderly subjects

• Váldodahkkit: Courtney Tiffany (Dahkki), Etienne F. Dumont (Dahkki), Mohammad Hossain (Dahkki), Meenakshi Srinivasan (Dahkki), Brandon Swift (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Wiley, 2022-09-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Abstract Gepotidacin, a novel, first‐in‐class triazaacenaphthylene antibiotic, inhibits bacterial DNA replication by a distinct mechanism of action. We report the pharmacokinetics (PKs), safety, and tolerability of gepotidacin following single or multiple ascending doses. Studies 1 and 2 were random...