Polaprezinc (Zinc L-Carnosine) Is a Potent Inducer of Anti-oxidative Stress Enzyme, Heme Oxygenase (HO)-1 - a New Mechanism of Gastric Mucosal Protection

• Hauptverfasser: Kazuki Ueda (Verfasst von), Takashi Ueyama (Verfasst von), Masashi Oka (Verfasst von), Takao Ito (Verfasst von), Yoshihiro Tsuruo (Verfasst von), Masao Ichinose (Verfasst von)
• Format: Buch
• Veröffentlicht: Elsevier, 2009-01-01T00:00:00Z.
• Schlagworte: article
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Abstract.: Heme oxygenase (HO)-1 is implicated in cytoprotection in various organs. We tested a possibility that polaprezinc (PZ), an anti-ulcer drug, could induce HO-1 in the gastric mucosa. Male 6-week-old Wistar rats were intragastrically administered PZ. Gastric expression of HO-1 was assessed b...