Polaprezinc (Zinc L-Carnosine) Is a Potent Inducer of Anti-oxidative Stress Enzyme, Heme Oxygenase (HO)-1 - a New Mechanism of Gastric Mucosal Protection

• Main Authors: Kazuki Ueda (Author), Takashi Ueyama (Author), Masashi Oka (Author), Takao Ito (Author), Yoshihiro Tsuruo (Author), Masao Ichinose (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: Heme oxygenase (HO)-1 is implicated in cytoprotection in various organs. We tested a possibility that polaprezinc (PZ), an anti-ulcer drug, could induce HO-1 in the gastric mucosa. Male 6-week-old Wistar rats were intragastrically administered PZ. Gastric expression of HO-1 was assessed b...