Dimethyl Fumarate Protects Retinal Pigment Epithelium from Blue Light-Induced Oxidative Damage via the Nrf2 Pathway

• Autors principals: Hideyuki Shimizu (Autor), Kei Takayama (Autor), Kazuhisa Yamada (Autor), Ayana Suzumura (Autor), Tomohito Sato (Autor), Yoshiaki Nishio (Autor), Masataka Ito (Autor), Hiroaki Ushida (Autor), Koji M Nishiguchi (Autor), Masaru Takeuchi (Autor), Hiroki Kaneko (Autor)
• Format: Llibre
• Publicat: MDPI AG, 2022-12-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

The purpose of this study is to investigate the protective effect of dimethyl fumarate (DMF), the methyl-ester of fumaric acid, against blue-light (BL) exposure in retinal pigment epithelial (RPE) cells. ARPE-19 cells, a human RPE cell line, were cultured with DMF followed by exposure to BL. Reactiv...