Dimethyl Fumarate Protects Retinal Pigment Epithelium from Blue Light-Induced Oxidative Damage via the Nrf2 Pathway

• Main Authors: Hideyuki Shimizu (Author), Kei Takayama (Author), Kazuhisa Yamada (Author), Ayana Suzumura (Author), Tomohito Sato (Author), Yoshiaki Nishio (Author), Masataka Ito (Author), Hiroaki Ushida (Author), Koji M Nishiguchi (Author), Masaru Takeuchi (Author), Hiroki Kaneko (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The purpose of this study is to investigate the protective effect of dimethyl fumarate (DMF), the methyl-ester of fumaric acid, against blue-light (BL) exposure in retinal pigment epithelial (RPE) cells. ARPE-19 cells, a human RPE cell line, were cultured with DMF followed by exposure to BL. Reactiv...