Hypomethylating Chemotherapeutic Agents as Therapy for Myelodysplastic Syndromes and Prevention of Acute Myeloid Leukemia

• Auteurs principaux: Vincent G. Sorrentino (Auteur), Srijan Thota (Auteur), Edward A. Gonzalez (Auteur), Pranela Rameshwar (Auteur), Victor T. Chang (Auteur), Jean-Pierre Etchegaray (Auteur)
• Format: Livre
• Publié: MDPI AG, 2021-07-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Myelodysplastic Syndromes (MDSs) affect the elderly and can progress to Acute Myeloid Leukemia (AML). Epigenetic alterations including DNA methylation and chromatin modification may contribute to the initiation and progression of these malignancies. DNA hypomethylating agents such as decitabine and...