Synthesis of [18F]FMISO, a hypoxia-specific imaging probe for PET, an overview from a radiochemist's perspective

• Main Authors: Torsten Kniess (Author), Jörg Zessin (Author), Peter Mäding (Author), Manuela Kuchar (Author), Oliver Kiss (Author), Klaus Kopka (Author)
• 格式: 圖書
• 出版: SpringerOpen, 2023-03-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Abstract Background [18F]fluoromisonidazole ([18F]FMISO, 1H-1-(3-[18F]fluoro-2-hydroxypropyl)-2-nitroimidazole) is a commonly used radiotracer for imaging hypoxic conditions in cells. Since hypoxia is prevalent in solid tumors, [18F]FMISO is in clinical application for decades to explore oxygen dema...