Protein Kinase C-δ Mediates Shedding of Angiotensin-Converting Enzyme 2 from Proximal Tubular Cells

• Egile Nagusiak: Fengxia eXiao (Egilea), Joseph eZimpelmann (Egilea), Dylan eBurger (Egilea), Chris RJ Kennedy (Egilea), Richard eHebert (Egilea), Kevin D Burns (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2016-06-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Angiotensin-converting enzyme 2 (ACE2) degrades angiotensin (Ang) II to Ang-(1-7), and protects against diabetic renal injury. Soluble ACE2 fragments are shed from the proximal tubule, and appear at high levels in the urine with diabetes. High glucose-induced shedding of ACE2 from proximal tubular c...