Protein Kinase C-δ Mediates Shedding of Angiotensin-Converting Enzyme 2 from Proximal Tubular Cells

• Main Authors: Fengxia eXiao (Author), Joseph eZimpelmann (Author), Dylan eBurger (Author), Chris RJ Kennedy (Author), Richard eHebert (Author), Kevin D Burns (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Angiotensin-converting enzyme 2 (ACE2) degrades angiotensin (Ang) II to Ang-(1-7), and protects against diabetic renal injury. Soluble ACE2 fragments are shed from the proximal tubule, and appear at high levels in the urine with diabetes. High glucose-induced shedding of ACE2 from proximal tubular c...