The central nervous system is a potential reservoir and possible origin of drug resistance in hepatitis B infection

• Main Authors: Lijun Xu (Author), Minghan Zhou (Author), Xiuming Peng (Author), Yufan Xu (Author), Fan Huang (Author), Linyun Wang (Author), Xiaorong Peng (Author), Zongxing Yang (Author), Ran Tao (Author), Guanjing Lang (Author), Qing Cao (Author), Minwei Li (Author), Ying Huang (Author), Biao Zhu (Author), Yan Xu (Author)
• Format: Book
• Published: Elsevier, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: The significance of hepatitis B virus (HBV) in cerebrospinal fluid (CSF) is unclear. Methods: Synchronous serum and CSF samples were collected from 13 patients. HBV DNA, full-length genome, quasispecies, phylogenetic tree, compartmentalization and mutation of the reverse transcriptase (R...