Identification and in vitro validation of neoantigens for immune activation against high-risk pediatric leukemia cells

• Main Authors: Satbir Thakur (Author), Mohit Jain (Author), Chunfen Zhang (Author), Candice Major (Author), Kevin J. Bielamowicz (Author), Norman J. Lacayo (Author), Olena Vaske (Author), Victor Lewis (Author), Luis Murguia-Favela (Author), Aru Narendran (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

There is experimental and clinical data to indicate the contribution of immune-escape mechanisms in relapsed/refractory pediatric leukemia. Studies have shown the accumulation of mutations that translate to peptides containing tumor-specific epitopes (neoantigens). The effectiveness of neoantigen-ba...