Brugia malayi microfilariae adhere to human vascular endothelial cells in a C3-dependent manner.

• Main Authors: Jan-Hendrik Schroeder (Author), David McCarthy (Author), Tadge Szestak (Author), Darren A Cook (Author), Mark J Taylor (Author), Alister G Craig (Author), Charlotte Lawson (Author), Rachel A Lawrence (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Brugia malayi causes the human tropical disease, lymphatic filariasis. Microfilariae (Mf) of this nematode live in the bloodstream and are ingested by a feeding mosquito vector. Interestingly, in a remarkable co-evolutionary adaptation, Mf appearance in the peripheral blood follows a circadian perio...