Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes

• Главные авторы: Samantha E. Adamson (Автор), Akshaya K. Meher (Автор), Yu-hsin Chiu (Автор), Joanna K. Sandilos (Автор), Nathaniel P. Oberholtzer (Автор), Natalie N. Walker (Автор), Stefan R. Hargett (Автор), Scott A. Seaman (Автор), Shayn M. Peirce-Cottler (Автор), Brant E. Isakson (Автор), Coleen A. McNamara (Автор), Susanna R. Keller (Автор), Thurl E. Harris (Автор), Douglas A. Bayliss (Автор), Norbert Leitinger (Автор)
• Формат: ‌
• Опубликовано: Elsevier, 2015-09-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Objective: Defective glucose uptake in adipocytes leads to impaired metabolic homeostasis and insulin resistance, hallmarks of type 2 diabetes. Extracellular ATP-derived nucleotides and nucleosides are important regulators of adipocyte function, but the pathway for controlled ATP release from adipoc...