Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes

• Main Authors: Samantha E. Adamson (Author), Akshaya K. Meher (Author), Yu-hsin Chiu (Author), Joanna K. Sandilos (Author), Nathaniel P. Oberholtzer (Author), Natalie N. Walker (Author), Stefan R. Hargett (Author), Scott A. Seaman (Author), Shayn M. Peirce-Cottler (Author), Brant E. Isakson (Author), Coleen A. McNamara (Author), Susanna R. Keller (Author), Thurl E. Harris (Author), Douglas A. Bayliss (Author), Norbert Leitinger (Author)
• Format: Book
• Published: Elsevier, 2015-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Defective glucose uptake in adipocytes leads to impaired metabolic homeostasis and insulin resistance, hallmarks of type 2 diabetes. Extracellular ATP-derived nucleotides and nucleosides are important regulators of adipocyte function, but the pathway for controlled ATP release from adipoc...