Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes

• Autori principali: Samantha E. Adamson (Autore), Akshaya K. Meher (Autore), Yu-hsin Chiu (Autore), Joanna K. Sandilos (Autore), Nathaniel P. Oberholtzer (Autore), Natalie N. Walker (Autore), Stefan R. Hargett (Autore), Scott A. Seaman (Autore), Shayn M. Peirce-Cottler (Autore), Brant E. Isakson (Autore), Coleen A. McNamara (Autore), Susanna R. Keller (Autore), Thurl E. Harris (Autore), Douglas A. Bayliss (Autore), Norbert Leitinger (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2015-09-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Objective: Defective glucose uptake in adipocytes leads to impaired metabolic homeostasis and insulin resistance, hallmarks of type 2 diabetes. Extracellular ATP-derived nucleotides and nucleosides are important regulators of adipocyte function, but the pathway for controlled ATP release from adipoc...