Oleanolic acid attenuates TGF-β1-induced epithelial-mesenchymal transition in NRK-52E cells

• Main Authors: Wei-ming He (Author), Jia-qi Yin (Author), Xu-dong Cheng (Author), Xun Lu (Author), Li Ni (Author), Yi Xi (Author), Gui-dong Yin (Author), Guo-yuan Lu (Author), Wei Sun (Author), Ming-gang Wei (Author)
• Format: Book
• Published: BMC, 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Epithelial-to-mesenchymal transition (EMT) plays an important role in the progression of renal interstitial fibrosis, which finally leads to renal failure. Oleanolic acid (OA), an activator of NF-E2-related factor 2 (Nrf2), is reported to attenuate renal fibrosis in mice with uni...