Stimulation of Histamine H1 Receptor Up-Regulates Histamine H1 Receptor Itself Through Activation of Receptor Gene Transcription

• Main Authors: Asish K. Das (Author), Sachiho Yoshimura (Author), Ryoko Mishima (Author), Katsumi Fujimoto (Author), Hiroyuki Mizuguchi (Author), Shrabanti Dev (Author), Yousuke Wakayama (Author), Yoshiaki Kitamura (Author), Shuhei Horio (Author), Noriaki Takeda (Author), Hiroyuki Fukui (Author)
• Format: Book
• Published: Elsevier, 2007-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Histamine is a major mediator in allergy acting mainly through the histamine H1 receptor (H1R). Although H1R up-regulation has been suggested as an important step for induction of allergic symptoms, little is known about the regulation of H1R level. Here we report that the activation of H1R up-regul...