Qualification and Application of a Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometric Method for the Determination of Adalimumab in Rat Plasma

• Hoofdauteurs: Yuri Park (Auteur), Nahye Kim (Auteur), Jangmi Choi (Auteur), Min-Ho Park (Auteur), Byeong ill Lee (Auteur), Seok-Ho Shin (Auteur), Jin-Ju Byeon (Auteur), Young G. Shin (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2018-05-01T00:00:00Z.
• Onderwerpen: article
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A liquid chromatography–quadrupole time-of-flight (Q-TOF) mass spectrometric method was developed for early-stage research on adalimumab in rats. The method consisted of immunoprecipitation followed by tryptic digestion for sample preparation and LC-QTOF-MS/MS analysis of specific signatur...