Qualification and Application of a Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometric Method for the Determination of Adalimumab in Rat Plasma

• Main Authors: Yuri Park (Author), Nahye Kim (Author), Jangmi Choi (Author), Min-Ho Park (Author), Byeong ill Lee (Author), Seok-Ho Shin (Author), Jin-Ju Byeon (Author), Young G. Shin (Author)
• Format: Book
• Published: MDPI AG, 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A liquid chromatography–quadrupole time-of-flight (Q-TOF) mass spectrometric method was developed for early-stage research on adalimumab in rats. The method consisted of immunoprecipitation followed by tryptic digestion for sample preparation and LC-QTOF-MS/MS analysis of specific signatur...