A Multicentre Pilot Study of a Two-Tier Newborn Sickle Cell Disease Screening Procedure with a First Tier Based on a Fully Automated MALDI-TOF MS Platform

• Prif Awduron: Pierre Naubourg (Awdur), Marven El Osta (Awdur), David Rageot (Awdur), Olivier Grunewald (Awdur), Gilles Renom (Awdur), Patrick Ducoroy (Awdur), Jean-Marc Périni (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: MDPI AG, 2019-01-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

The reference methods used for sickle cell disease (SCD) screening usually include two analytical steps: a first tier for differentiating haemoglobin S (HbS) heterozygotes, HbS homozygotes and β-thalassemia from other samples, and a confirmatory second tier. Here, we evaluated a first-tier approach...