A Multicentre Pilot Study of a Two-Tier Newborn Sickle Cell Disease Screening Procedure with a First Tier Based on a Fully Automated MALDI-TOF MS Platform

• Glavni autori: Pierre Naubourg (Autor), Marven El Osta (Autor), David Rageot (Autor), Olivier Grunewald (Autor), Gilles Renom (Autor), Patrick Ducoroy (Autor), Jean-Marc Périni (Autor)
• Format: Knjiga
• Izdano: MDPI AG, 2019-01-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

The reference methods used for sickle cell disease (SCD) screening usually include two analytical steps: a first tier for differentiating haemoglobin S (HbS) heterozygotes, HbS homozygotes and β-thalassemia from other samples, and a confirmatory second tier. Here, we evaluated a first-tier approach...