PGC-1α-Dependent Mitochondrial Adaptation Is Necessary to Sustain IL-2-Induced Activities in Human NK Cells

• Päätekijät: Dante Miranda (Tekijä), Claudia Jara (Tekijä), Jorge Ibañez (Tekijä), Viviana Ahumada (Tekijä), Claudio Acuña-Castillo (Tekijä), Adrian Martin (Tekijä), Alexandra Córdova (Tekijä), Margarita Montoya (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Hindawi Limited, 2016-01-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Human Natural Killer (NK) cells are a specialized heterogeneous subpopulation of lymphocytes involved in antitumor defense reactions. NK cell effector functions are critically dependent on cytokines and metabolic activity. Among various cytokines modulating NK cell function, interleukin-2 (IL-2) can...