ACAT1 deficiency in myeloid cells promotes glioblastoma progression by enhancing the accumulation of myeloid-derived suppressor cells

• Egile Nagusiak: Mingjin Wang (Egilea), Weida Wang (Egilea), Shen You (Egilea), Zhenyan Hou (Egilea), Ming Ji (Egilea), Nina Xue (Egilea), Tingting Du (Egilea), Xiaoguang Chen (Egilea), Jing Jin (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2023-12-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Glioblastoma (GBM) is a highly aggressive and lethal brain tumor with an immunosuppressive tumor microenvironment (TME). In this environment, myeloid cells, such as myeloid-derived suppressor cells (MDSCs), play a pivotal role in suppressing antitumor immunity. Lipometabolism is closely related to t...