ACAT1 deficiency in myeloid cells promotes glioblastoma progression by enhancing the accumulation of myeloid-derived suppressor cells

• Main Authors: Mingjin Wang (Author), Weida Wang (Author), Shen You (Author), Zhenyan Hou (Author), Ming Ji (Author), Nina Xue (Author), Tingting Du (Author), Xiaoguang Chen (Author), Jing Jin (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glioblastoma (GBM) is a highly aggressive and lethal brain tumor with an immunosuppressive tumor microenvironment (TME). In this environment, myeloid cells, such as myeloid-derived suppressor cells (MDSCs), play a pivotal role in suppressing antitumor immunity. Lipometabolism is closely related to t...