IGF2 deficiency promotes liver aging through mitochondrial dysfunction and upregulated CEBPB signaling in d-galactose-induced aging mice

• Главные авторы: Xiaohai Zhou (Автор), Bowen Tan (Автор), Weiwei Gui (Автор), Caiping Zhou (Автор), Hanxin Zhao (Автор), Xihua Lin (Автор), Hong Li (Автор)
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• Опубликовано: BMC, 2023-11-01T00:00:00Z.
• Предметы: article
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Abstract Background Liver aging, marked by cellular senescence and low-grade inflammation, heightens susceptibility to chronic liver disease and worsens its prognosis. Insulin-like growth factor 2 (IGF2) has been implicated in numerous aging-related diseases. Nevertheless, its role and underlying mo...