GLS and GLS2 Glutaminase Isoenzymes in the Antioxidant System of Cancer Cells

• Váldodahkkit: Juan De los Santos-Jiménez (Dahkki), José A. Campos-Sandoval (Dahkki), Francisco J. Alonso (Dahkki), Javier Márquez (Dahkki), José M. Matés (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2024-06-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

A pathway frequently altered in cancer is glutaminolysis, whereby glutaminase (GA) catalyzes the main step as follows: the deamidation of glutamine to form glutamate and ammonium. There are two types of GA isozymes, named GLS and GLS2, which differ considerably in their expression patterns and can e...