GLS and GLS2 Glutaminase Isoenzymes in the Antioxidant System of Cancer Cells

• मुख्य लेखकों: Juan De los Santos-Jiménez (लेखक), José A. Campos-Sandoval (लेखक), Francisco J. Alonso (लेखक), Javier Márquez (लेखक), José M. Matés (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2024-06-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

A pathway frequently altered in cancer is glutaminolysis, whereby glutaminase (GA) catalyzes the main step as follows: the deamidation of glutamine to form glutamate and ammonium. There are two types of GA isozymes, named GLS and GLS2, which differ considerably in their expression patterns and can e...