Expansion in CD39⁺ CD4⁺ immunoregulatory t cells and rarity of Th17 cells in HTLV-1 infected patients is associated with neurological complications.

• Main Authors: Fabio E Leal (Author), Lishomwa C Ndhlovu (Author), Aaron M Hasenkrug (Author), Fernanda R Bruno (Author), Karina I Carvalho (Author), Harry Wynn-Williams (Author), Walter K Neto (Author), Sabri S Sanabani (Author), Aluisio C Segurado (Author), Douglas F Nixon (Author), Esper G Kallas (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

HTLV-1 infection is associated with several inflammatory disorders, including the neurodegenerative condition HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). It is unclear why a minority of infected subjects develops HAM/TSP. CD4⁺ T cells are the main target of infection and pla...