Expansion in CD39⁺ CD4⁺ immunoregulatory t cells and rarity of Th17 cells in HTLV-1 infected patients is associated with neurological complications.

• Hoofdauteurs: Fabio E Leal (Auteur), Lishomwa C Ndhlovu (Auteur), Aaron M Hasenkrug (Auteur), Fernanda R Bruno (Auteur), Karina I Carvalho (Auteur), Harry Wynn-Williams (Auteur), Walter K Neto (Auteur), Sabri S Sanabani (Auteur), Aluisio C Segurado (Auteur), Douglas F Nixon (Auteur), Esper G Kallas (Auteur)
• Formaat: Boek
• Gepubliceerd in: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

HTLV-1 infection is associated with several inflammatory disorders, including the neurodegenerative condition HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). It is unclear why a minority of infected subjects develops HAM/TSP. CD4⁺ T cells are the main target of infection and pla...