Shedding of Microvesicles from Microglia Contributes to the Effects Induced by Metabotropic Glutamate Receptor 5 Activation on Neuronal Death

• Главные авторы: Martina Beneventano (Автор), Simona F. Spampinato (Автор), Sara Merlo (Автор), Mariangela Chisari (Автор), Paola Platania (Автор), Marco Ragusa (Автор), Michele Purrello (Автор), Ferdinando Nicoletti (Автор), Maria Angela Sortino (Автор)
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• Опубликовано: Frontiers Media S.A., 2017-11-01T00:00:00Z.
• Предметы: article
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Metabotropic glutamate (mGlu) receptor 5 is involved in neuroinflammation and has been shown to mediate reduced inflammation and neurotoxicity and to modify microglia polarization. On the other hand, blockade of mGlu5 receptor results in inhibition of microglia activation. To dissect this controvers...