Shedding of Microvesicles from Microglia Contributes to the Effects Induced by Metabotropic Glutamate Receptor 5 Activation on Neuronal Death

• Main Authors: Martina Beneventano (Author), Simona F. Spampinato (Author), Sara Merlo (Author), Mariangela Chisari (Author), Paola Platania (Author), Marco Ragusa (Author), Michele Purrello (Author), Ferdinando Nicoletti (Author), Maria Angela Sortino (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Metabotropic glutamate (mGlu) receptor 5 is involved in neuroinflammation and has been shown to mediate reduced inflammation and neurotoxicity and to modify microglia polarization. On the other hand, blockade of mGlu5 receptor results in inhibition of microglia activation. To dissect this controvers...