Caffeine reduces deficits in mechanosensation and locomotion induced by L-DOPA and protects dopaminergic neurons in a transgenic Caenorhabditis elegans model of Parkinson's disease

• मुख्य लेखकों: Rafael Vincent M. Manalo (लेखक), Paul Mark B. Medina (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Context L-DOPA is the first-line drug for Parkinson's disease (PD). However, chronic use can lead to dyskinesia. Caffeine, which is a known neuroprotectant, can potentially act as an adjunct to minimise adverse effects of L-DOPA. Objectives This study determined changes in terms of neurodegener...