Virtual Screening Based on Machine Learning Explores Mangrove Natural Products as KRAS^G12C Inhibitors

• Main Authors: Lianxiang Luo (Author), Tongyu Zheng (Author), Qu Wang (Author), Yingling Liao (Author), Xiaoqi Zheng (Author), Ai Zhong (Author), Zunnan Huang (Author), Hui Luo (Author)
• Format: Book
• Published: MDPI AG, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mangrove secondary metabolites have many unique biological activities. We identified lead compounds among them that might target KRAS^G12C<b>.</b> KRAS is considered to be closely related to various cancers. A variety of novel small molecules that directly target KR...