Density functional theory (DFT), molecular docking, and xanthine oxidase inhibitory studies of dinaphthodiospyrol S from Diospyros kaki L

• Main Authors: Tareq Abu-Izneid (Author), Abdur Rauf (Author), Zubair Ahmad (Author), Abdul Wadood (Author), Khurshid Ayub (Author), Naveed Muhammad (Author), Yahya S. Al-Awthan (Author), Maria Maqbool (Author), Omar S. Bahattab (Author), Hassan A. Hemeg (Author), Saima Naz (Author), Dorota Formanowicz (Author)
• Format: Book
• Published: Elsevier, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this work, we investigated Diospyros kaki extract and an isolated compound for their potential as xanthine oxidase (XO) inhibitors, a target enzyme involved in inflammatory disorders. The prepared extract was subjected to column chromatography, and dinaphthodiospyrol S was isolated. Then XO inhib...