Matrix Gla protein negatively regulates calcification of human aortic valve interstitial cells isolated from calcified aortic valves

• Main Authors: Mari Chiyoya (Author), Kazuhiko Seya (Author), Zaiqiang Yu (Author), Kazuyuki Daitoku (Author), Shigeru Motomura (Author), Tadaatsu Imaizumi (Author), Ikuo Fukuda (Author), Ken-Ichi Furukawa (Author)
• Format: Book
• Published: Elsevier, 2018-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Calcified aortic valve stenosis (CAS) is a common heart valve disease in elderly people, and is mostly accompanied by ectopic valve calcification. We recently demonstrated that tumor necrosis factor-α (TNF-α) induces calcification of human aortic valve interstitial cells (HAVICs) obtained from CAS p...