Binding of CLL Subset 4 B Cell Receptor Immunoglobulins to Viable Human Memory B Lymphocytes Requires a Distinctive IGKV Somatic Mutation

• Главные авторы: Rosa Catera (Автор), Yun Liu (Автор), Chao Gao (Автор), Xiao-Jie Yan (Автор), Amanda Magli (Автор), Steven L. Allen (Автор), Jonathan E. Kolitz (Автор), Kanti R. Rai (Автор), Charles C. Chu (Автор), Ten Feizi (Автор), Kostas Stamatopoulos (Автор), Nicholas Chiorazzi (Автор)
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• Опубликовано: BMC, 2017-01-01T00:00:00Z.
• Предметы: article
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Abstract Amino acid replacement mutations in certain chronic lymphocytic leukemia (CLL) stereotyped B cell receptor (BCR) immunoglobulins (IGs) at defined positions within antigen-binding sites strongly imply antigen selection. Prime examples of this are CLL subset 4 BCR IGs using IGHV4-34/IGHD5-18/...