GENE-IS: Time-Efficient and Accurate Analysis of Viral Integration Events in Large-Scale Gene Therapy Data

• Main Authors: Saira Afzal (Author), Stefan Wilkening (Author), Christof von Kalle (Author), Manfred Schmidt (Author), Raffaele Fronza (Author)
• 格式: 圖書
• 出版: Elsevier, 2017-03-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Integration site profiling and clonality analysis of viral vector distribution in gene therapy is a key factor to monitor the fate of gene-corrected cells, assess the risk of malignant transformation, and establish vector biosafety. We developed the Genome Integration Site Analysis Pipeline (GENE-IS...