Early and consistent overexpression of ADRM1 in ovarian high-grade serous carcinoma

• Main Authors: Rosie T. Jiang (Author), Anna Yemelyanova (Author), Deyin Xing (Author), Ravi K. Anchoori (Author), Jun Hamazaki (Author), Shigeo Murata (Author), Jeffrey D. Seidman (Author), Tian-Li Wang (Author), Richard B. S. Roden (Author)
• Format: Book
• Published: BMC, 2017-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Ovarian carcinoma is highly dependent on the ubiquitin proteasome system (UPS), but its clinical response to treatment with the proteasome inhibitor bortezomib has been disappointing. This has driven exploration of alternate approaches to target the UPS in ovarian cancer. Recentl...