Administration of Bicarbonate Protects Mitochondria, Rescues Retinal Ganglion Cells, and Ameliorates Visual Dysfunction Caused by Oxidative Stress

• Päätekijät: Tonking Bastola (Tekijä), Guy A. Perkins (Tekijä), Viet Anh Nguyen Huu (Tekijä), Saeyeon Ju (Tekijä), Keun-Young Kim (Tekijä), Ziyao Shen (Tekijä), Dorota Skowronska-Krawczyk (Tekijä), Robert N. Weinreb (Tekijä), Won-Kyu Ju (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: MDPI AG, 2024-06-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Oxidative stress is a key factor causing mitochondrial dysfunction and retinal ganglion cell (RGC) death in glaucomatous neurodegeneration. The cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) signaling pathway is involved in mitochondrial protection, promoting RGC survival. Soluble aden...