Administration of Bicarbonate Protects Mitochondria, Rescues Retinal Ganglion Cells, and Ameliorates Visual Dysfunction Caused by Oxidative Stress

• Main Authors: Tonking Bastola (Author), Guy A. Perkins (Author), Viet Anh Nguyen Huu (Author), Saeyeon Ju (Author), Keun-Young Kim (Author), Ziyao Shen (Author), Dorota Skowronska-Krawczyk (Author), Robert N. Weinreb (Author), Won-Kyu Ju (Author)
• Format: Book
• Published: MDPI AG, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxidative stress is a key factor causing mitochondrial dysfunction and retinal ganglion cell (RGC) death in glaucomatous neurodegeneration. The cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) signaling pathway is involved in mitochondrial protection, promoting RGC survival. Soluble aden...