The Importance of Being Profiled: Improving Drug Candidate Safety and Efficacy Using Ion Channel Profiling

• المؤلفون الرئيسيون: Gregory J. Kaczorowski (مؤلف), Maria L. Garcia (مؤلف), Jacob eBode (مؤلف), Stephen D. Hess (مؤلف), Umesh A. Patel (مؤلف)
• التنسيق: كتاب
• منشور في: Frontiers Media S.A., 2011-12-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Profiling of putative lead compounds against a representative panel of relevant enzymes, receptors, ion channels and transporters is a pragmatic approach to establish a preliminary view of potential issues that might later hamper development. An early idea of which off-target activities must be mini...