The Importance of Being Profiled: Improving Drug Candidate Safety and Efficacy Using Ion Channel Profiling

• Main Authors: Gregory J. Kaczorowski (Author), Maria L. Garcia (Author), Jacob eBode (Author), Stephen D. Hess (Author), Umesh A. Patel (Author)
• Format: Book
• Published: Frontiers Media S.A., 2011-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Profiling of putative lead compounds against a representative panel of relevant enzymes, receptors, ion channels and transporters is a pragmatic approach to establish a preliminary view of potential issues that might later hamper development. An early idea of which off-target activities must be mini...