Exploring the Trypanosoma brucei Hsp83 potential as a target for structure guided drug design.

• Автори: Juan Carlos Pizarro (Автор), Tanya Hills (Автор), Guillermo Senisterra (Автор), Amy K Wernimont (Автор), Claire Mackenzie (Автор), Neil R Norcross (Автор), Michael A J Ferguson (Автор), Paul G Wyatt (Автор), Ian H Gilbert (Автор), Raymond Hui (Автор)
• Формат: Книга
• Опубліковано: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Human African trypanosomiasis is a neglected parasitic disease that is fatal if untreated. The current drugs available to eliminate the causative agent Trypanosoma brucei have multiple liabilities, including toxicity, increasing problems due to treatment failure and limited efficacy. There are two a...