Exploring the Trypanosoma brucei Hsp83 potential as a target for structure guided drug design.

• Main Authors: Juan Carlos Pizarro (Author), Tanya Hills (Author), Guillermo Senisterra (Author), Amy K Wernimont (Author), Claire Mackenzie (Author), Neil R Norcross (Author), Michael A J Ferguson (Author), Paul G Wyatt (Author), Ian H Gilbert (Author), Raymond Hui (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human African trypanosomiasis is a neglected parasitic disease that is fatal if untreated. The current drugs available to eliminate the causative agent Trypanosoma brucei have multiple liabilities, including toxicity, increasing problems due to treatment failure and limited efficacy. There are two a...