Potential of IL-1, IL-18 and Inflammasome Inhibition for the Treatment of Inflammatory Skin Diseases

• 主要な著者: Gabriele Fenini (著者), Emmanuel Contassot (著者), Lars E. French (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2017-05-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

In 2002, intracellular protein complexes known as the inflammasomes were discovered and were shown to have a crucial role in the sensing of intracellular pathogen- and danger-associated molecular patterns (PAMPs and DAMPs). Activation of the inflammasomes results in the processing and subsequent sec...