Potential of IL-1, IL-18 and Inflammasome Inhibition for the Treatment of Inflammatory Skin Diseases

• Autori principali: Gabriele Fenini (Autore), Emmanuel Contassot (Autore), Lars E. French (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2017-05-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

In 2002, intracellular protein complexes known as the inflammasomes were discovered and were shown to have a crucial role in the sensing of intracellular pathogen- and danger-associated molecular patterns (PAMPs and DAMPs). Activation of the inflammasomes results in the processing and subsequent sec...