Cover Image

The influence of genetic polymorphisms in drug metabolism enzymes and transporters on the pharmacokinetics of different fluvastatin formulations

The purpose of the present study was to investigate the impact of genetic polymorphism on fluvastatin pharmacokinetics. In addition, we compared the fluvastatin pharmacokinetics differences between extended-release (ER) 80 mg tablet and immediate-release (IR) 40 mg capsule in terms of drug metabolis...

Full description

Saved in:

Bibliographic Details
Main Authors:	Qian Xiang (Author), Weidang Wu (Author), Nan Zhao (Author), Chuan Li (Author), Junyu Xu (Author), Lingyue Ma (Author), Xiaodan Zhang (Author), Qiufen Xie (Author), Zhuo Zhang (Author), Jiancheng Wang (Author), Weiren Xu (Author), Xia Zhao (Author), Yimin Cui (Author)
Format:	Book
Published:	Elsevier, 2020-03-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Enhanced oral bioavailability of fluvastatin by using nanosuspensions containing cyclodextrin
by: Li J, et al.
Published: (2018)

A Combined Pharmacometrics Analysis of Biomarker Distribution Under Treatment With Standard- or Low-Dose Rivaroxaban in Real-World Chinese Patients With Nonvalvular Atrial Fibrillation
by: Nan Zhao, et al.
Published: (2022)

Pharmacogenetics of Carbamazepine and Valproate: Focus on Polymorphisms of Drug Metabolizing Enzymes and Transporters
by: Teresa Iannaccone, et al.
Published: (2021)

Role of Fluvastatin sodium loaded polymeric nanoparticles in the treatment of Hyperlipidemia: Fabrication and Characterization
by: Avinash S Gudigennavar, et al.
Published: (2023)

Polymorphism of Drug Transporters, Rather Than Metabolizing Enzymes, Conditions the Pharmacokinetics of Rasagiline
by: Pablo Zubiaur, et al.
Published: (2022)

Genetic Polymorphisms of Pesticide-Metabolizing Enzymes and Transporters in Agricultural Workers and Thyroid Hormone Levels
by: Sirivarasai J, et al.
Published: (2021)

Comparative Lipid-Lowering/Increasing Efficacy of 7 Statins in Patients with Dyslipidemia, Cardiovascular Diseases, or Diabetes Mellitus: Systematic Review and Network Meta-Analyses of 50 Randomized Controlled Trials
by: Xiaodan Zhang, et al.
Published: (2020)

Effect of genetic polymorphisms on the interplay of P-glycoprotein transporter and cytochrome P450 enzymes: Pharmacokinetics of risperidone
by: Yong-Bok Lee
Published: (2016)

Fluvastatin promotes chondrogenic differentiation of adipose-derived mesenchymal stem cells by inducing bone morphogenetic protein 2
by: Masanari Kuwahara, et al.
Published: (2022)

Impact of polymorphisms in CYP and UGT enzymes and ABC and SLCO1B1 transporters on the pharmacokinetics and safety of desvenlafaxine
by: Sofía Calleja, et al.
Published: (2023)

Association of Drug-Metabolizing Enzyme and Transporter Gene Polymorphisms and Lipid-Lowering Response to Statins in Thai Patients with Dyslipidemia
by: Vanwong N, et al.
Published: (2022)

Repurposing of Fluvastatin as an Anticancer Agent against Breast Cancer Stem Cells via Encapsulation in a Hyaluronan-Conjugated Liposome
by: Ji Su Yu, et al.
Published: (2020)

Cytotoxic and Pro-Apoptotic Effects of a Sub-Toxic Concentration of Fluvastatin on OVCAR3 Ovarian Cancer Cells After its Optimized Formulation to Melittin Nano-Conjugates
by: Shaimaa M. Badr-Eldin, et al.
Published: (2021)

A Combination of Low Doses of Fluvastatin and Valsartan Decreases Arterial Stiffness in Patients After Myocardial Infarction: A Pilot Study
by: Jurij Hanžel, et al.
Published: (2015)

Development, Statistical Optimization and Characterization of Fluvastatin Loaded Solid Lipid Nanoparticles: A 3<sup>2</sup> Factorial Design Approach
by: Afzal Haq Asif, et al.
Published: (2022)

Diversity of Solid Forms Promoted by Ball Milling: Characterization and Intrinsic Dissolution Studies of Pioglitazone Hydrochloride and Fluvastatin Sodium Drug-Drug Systems
by: Marco Villeda-Villegas, et al.
Published: (2023)

Hematologic side effects of immune checkpoint inhibitor with or without chemotherapy in patients with advanced and metastatic gastrointestinal cancer: A systematic review and network meta-analysis of phase 3 trials
by: Jingyi Hou, et al.
Published: (2023)

Drug-induced fall risk in older patients: A pharmacovigilance study of FDA adverse event reporting system database
by: Shuang Zhou, et al.
Published: (2022)

Bioequivalence and pharmacodynamics of a generic dabigatran etexilate capsule in healthy Chinese subjects under fasting and fed conditions
by: Xin Li, et al.
Published: (2020)

Characterizing drug-metabolizing enzymes and transporters that are bona fide CAR-target genes in mouse intestine
by: Shinhee Park, et al.
Published: (2016)

Angiotensin-converting enzyme polymorphism and pediatric pneumonia
by: Nihal El Rifai, et al.
Published: (2018)

Physiologically‐based pharmacokinetic modeling predicts the drug interaction potential of GLS4 in co‐administered with ritonavir
by: Zexu Sun, et al.
Published: (2024)

The insertion/deletion (I/D) polymorphism in the <it>Angiotensin-converting enzyme </it>gene and cancer risk: a meta-analysis
by: Zhang Yonggang, et al.
Published: (2011)

Transporters (OATs and OATPs) contribute to illustrate the mechanism of medicinal compatibility of ingredients with different properties in yuanhuzhitong prescription
by: Ze Wang, et al.
Published: (2020)

Meta-analysis of the Association between Serotonin Transporter Polymorphisms and Sudden Infant Death Syndrome
by: Haojie Qin, et al.
Published: (2016)

Osteomalacia and renal failure due to Fanconi syndrome caused by long-term low-dose Adefovir Dipivoxil: a case report
by: Qian Xiang, et al.
Published: (2020)

Evaluation of the relationship between polymorphisms in CYP2C19 and the single‐dose pharmacokinetics of omeprazole in healthy Chinese volunteers: A multicenter study
by: Shuang Zhou, et al.
Published: (2022)

Association Between Genetic Polymorphisms of Metabolic Enzymes and Azathioprine-Induced Myelosuppression in 1,419 Chinese Patients: A Retrospective Study
by: Zhao-Yang Chen, et al.
Published: (2021)

Polymorphisms of Drug-Metabolizing Enzymes and Transporters Contribute to the Individual Variations of Erlotinib Steady State Trough Concentration, Treatment Outcomes, and Adverse Reactions in Epidermal Growth Factor Receptor-Mutated Non-Small Cell Lung Cancer Patients
by: Dehua Liao, et al.
Published: (2020)

Lack of association between PAX6/SOSTDC1/FAM20B gene polymorphisms and mesiodens
by: Shanshan Liu, et al.
Published: (2019)

Evaluation of the role of metabolizing enzymes and transporter variants in ezetimibe pharmacokinetics
by: Eva González-Iglesias, et al.
Published: (2024)

Pharmacogenomics of drug metabolizing enzymes and transporters: implications for cancer therapy
by: Bluth MH, et al.
Published: (2011)

POLYMORPHISM OF THE GENES OF ESTROGEN-METABOLISING ENZYMES IN PATIENTS WITH ENDOMETRIOSIS
by: Константин Сергеевич Кублинский, et al.
Published: (2017)

Risk of infection in roxadustat treatment for anemia in patients with chronic kidney disease: A systematic review with meta-analysis and trial sequential analysis
by: Shan Chong, et al.
Published: (2022)

A Preclinical Study of an <sup>125</sup>I-Labeled PSMA Ligand for Prostate-Cancer Puncture
by: Xiaohui Luan, et al.
Published: (2022)

Changes in Transporters and Metabolizing Enzymes in the Livers of Rats with Bile Duct Ligation
by: Atsushi Kawase, et al.
Published: (2019)

Genetic polymorphism of carcinogen metabolic enzymes in oral submucous fibrosis
by: Sunu Ramachandran, et al.
Published: (2022)

Antioxidant Enzymes Haplotypes and Polymorphisms Associated with Obesity in Mexican Children
by: Paula Costa-Urrutia, et al.
Published: (2020)

Transporter Associated with Antigen Processing 1 Gene Polymorphisms Increase the Susceptibility to Tuberculosis
by: Lu T, et al.
Published: (2023)

Transdermal delivery of fluvastatin sodium via tailored spanlastic nanovesicles: mitigated Freund's adjuvant-induced rheumatoid arthritis in rats through suppressing p38 MAPK signaling pathway
by: Shahira F. El Menshawe, et al.
Published: (2019)