Development of novel liver-targeting glucocorticoid prodrugs

• Main Authors: Yazheng Wang (Author), Dandan Guo (Author), Rebecca Winkler (Author), Xiaohong Lei (Author), Xiaojing Wang (Author), Jennifer Messina (Author), Juntao Luo (Author), Hong Lu (Author)
• Format: Book
• Published: Elsevier, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Glucocorticoids (GCs) are widely used in the treatment of inflammatory liver diseases and sepsis, but GC's various side effects on extrahepatic tissues limit their clinical benefits. Liver-targeting GC therapy may have multiple advantages over systemic GC therapy. The purpose of thi...