Increasing pro-survival factors within whole brain tissue of Sprague Dawley rats via intracerebral administration of modified valproic acid
Neural tissue exposure to valproic acid (VPA) increases several pro-survival phospho-proteins that can be used as biomarkers for indicating a beneficial drug response (pAktSer473, pGSK3βSer9, pErk1/2Thr202/Tyr204). Unfortunately, targeting VPA to neural tissue is a problem due to severe asymmetrical...
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Main Authors: | Ryan C. Bates (Author), Bradley J. Stith (Author), Karen E. Stevens (Author) |
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Format: | Book |
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Elsevier,
2015-08-01T00:00:00Z.
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Online Access: | Connect to this object online. |
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