Preparation of pegylated lumbrokinase and an evaluation of its thrombolytic activity both in vitro and in vivo

• Auteurs principaux: Mingji Jin (Auteur), Wei Chen (Auteur), Wei Huang (Auteur), Long Rong (Auteur), Zhonggao Gao (Auteur)
• Format: Livre
• Publié: Elsevier, 2013-04-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Lumbrokinase (LK) is a group of serine proteases with strong fibrinolytic and thrombolytic activities. In clinical practice, LK can only be administered orally because of its antigenicity, immunogenicity and potential to produce anaphylactic reactions after injection. However, many useful drugs such...