Pregnenolone 16-Alpha Carbonitrile, an Agonist of Rodent Pregnane X Receptor, Regulates Testosterone Biosynthesis in Rodent Leydig Cells

• Main Authors: Julia M. Salamat (Author), Elizabeth M. Ayala (Author), Chen-Che J. Huang (Author), Frank S. Wilbanks (Author), Rachel C. Knight (Author), Benson T. Akingbemi (Author), Satyanarayana R. Pondugula (Author)
• Format: Book
• Published: MDPI AG, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Leydig cells (LCs) in the testes produce the male sex hormone testosterone (T). Several xenobiotics, including clinical drugs, supplements, and environmental chemicals, are known to disrupt T homeostasis. Notably, some of these xenobiotics are known to activate the pregnane X receptor (PXR), a ligan...