Pregnenolone 16-Alpha Carbonitrile, an Agonist of Rodent Pregnane X Receptor, Regulates Testosterone Biosynthesis in Rodent Leydig Cells

• Asıl Yazarlar: Julia M. Salamat (Yazar), Elizabeth M. Ayala (Yazar), Chen-Che J. Huang (Yazar), Frank S. Wilbanks (Yazar), Rachel C. Knight (Yazar), Benson T. Akingbemi (Yazar), Satyanarayana R. Pondugula (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2024-09-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Leydig cells (LCs) in the testes produce the male sex hormone testosterone (T). Several xenobiotics, including clinical drugs, supplements, and environmental chemicals, are known to disrupt T homeostasis. Notably, some of these xenobiotics are known to activate the pregnane X receptor (PXR), a ligan...